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Greenville, South Carolina Hotels, Inns, Vacations and Travel Packages Or use our vacation planner to be contacted by our renowned Virtuoso Travel Agents, or just call: Travelwizard.com: Phone: 1-800-330-8820 or 1-415-446-5252 between 8:00 am and 5:00 Pacific Standard Greenville is a mid-sized city located in the upstate of South Carolina. It is the county seat of Greenville County and the principal city in the Greenville-Mauldin-Easley metropolitan area (MSA). As of the 2000 census, the city had a population of 56,006 people, and an urbanized area population of 302,194. As of the July 1, 2006 census estimates the Greenville Metropolitan Area (MSA) has a population of 601,986. Greenville is the largest city of the Greenville-Spartanburg-Anderson Combined Statistical Area (CSA) which has a 2006 estimated population of 1,203,795. The CSA, an 8-county region of northwestern South Carolina, is known as "The Upstate". Greenville is located approximately halfway between the cities of Atlanta, Georgia and Charlotte, North Carolina along Interstate I-85, and its metropolitan area is further serviced by I-385 and I-185. Please use our vacation planner to be contacted by our renowned Virtuoso Travel Agents, or just call: Travelwizard.com : 1-800-330-8820 or 1-415-446-5252 between 8:00 am and 5:00 Pacific Standard Time.
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